PQS Signaling for More than a Quorum: the Collective Stress Response Protects Healthy Pseudomonas aeruginosa Populations

The Pseudomonas Quinolone Signal (PQS) Balances Life and Death in Pseudomonas aeruginosa Populations

When environmental conditions deteriorate and become inhospitable, generic survival strategies for populations of bacteria may be to enter a dormant state that slows down metabolism, to develop a general tolerance to hostile parameters that characterize the habitat, and to impose a regime to eliminate damaged members. Here, we provide evidence that the pseudomonas quinolone signal (PQS) mediate...

Conversion of the Pseudomonas aeruginosa Quinolone Signal ( PQS ) and Related

Correction: Dynorphin Activates Quorum Sensing Quinolone Signaling in Pseudomonas aeruginosa

Pseudomonas aeruginosa Olga Zaborina, Francois Lepine, Gaoping Xiao, Vesta Valuckaite, Yimei Chen, Terry Li, Mae Ciancio, Alex Zaborin, Elaine O. Petrof, Jerrold R. Turner, Laurence G. Rahme, Eugene Chang, John C. Alverdy doi: 10.1371/journal.ppat.0030035 In PLoS Pathogens, vol 3, issue 3: One of the authors, Dr. Elaine O. Petrof, was incorrectly listed as Elaine Petroff. This correction note m...

Pseudomonas aeruginosa increases formation of multidrug-tolerant persister cells in response to quorum-sensing signaling molecules.

Bacterial persister cells constitute a small portion of a culture which is tolerant to killing by lethal doses of bactericidal antibiotics. These phenotypic variants are formed in numerous bacterial species, including those with clinical relevance like the opportunistic pathogen Pseudomonas aeruginosa. Although persisters are believed to contribute to difficulties in the treatment of many infec...

Quorum Sensing Protects Pseudomonas aeruginosa against Cheating by Other Species in a Laboratory Coculture Model.

UNLABELLED Many species of bacteria use a cell-cell communication system called quorum sensing (QS) to coordinate group activities. QS systems frequently regulate the production of exoproducts. Some of these products, such as proteases, are "public goods" that are shared among the population and vulnerable to cheating by nonproducing members of the population. Because the QS system of the oppor...